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KMID : 0043319860090010049
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Archives of Pharmacal Research
1986 Volume.9 No. 1 p.49 ~ p.54
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Effect of Ion-Pair Complexation with Bile Acids on the Biliary Excretion and Systemic Distribution of Organic Cationic Drugs
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Shim CK
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Abstract
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Effect of sodium taurodeoxycholate (TDC) infused intravenously on the pharmacokinetics of methylene blue (MB) was studied in the rat to investigate the role of ion-pair complexation in the body on drug elimination and disposition. Distribution volume (Vd) of MB was increased significantly (p<0.05) by TDC infusion. Considering together with the fact that apparent partition coefficient (APC) of MB between phosphate buffer (pH 7.4) and n-octanol was increased markedly by TDC, the increase in Vd seemed to be the result of decreased polarity of MB by ion-pair formation with TDC. But total body clearance (CLt) and biliary excretion clearance (CLbil) of MB were not increased significantly by TDC.
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KEYWORD
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